Green Tea May Prevent Diabetes type 2

Green tea extract may help avoid type-2 diabetes through enhanced glucose tolerance

(NewsTarget) New research by DSM Nutritional Products shows that epigallocatechin gallate, commonly known as EGCG, enhances glucose tolerance within diabetic rodents and could be a positive add-on to dietary protection against type 2 diabetes, if the results can be applied to humans.

"To our knowledge, we provide the first evidence which EGCG consumed in the diet plan exerts potent antidiabetic activity in vivo in a dose-dependent manner," wrote lead author Swen Wolfram of DSM within the Journal of Nutrition.

The study looked at 37 male mice have been severely diabetic, as well as divided them in to four groups. The actual rats were given 2.5, Five or ten grams of EGCG per kilogram of diet plan, or a placebo, for 7 weeks.

At the five-week mark, the researchers tested oral glucose tolerance and found that glucose levels decreased by 23, Thirty-five and 48 percent in the 2.5-, 5- and 10-gram categories respectively. From six weeks into the study, the scientists tested insulin tolerance and blood samples were taken at the end of the check to analyze glucose, totally free fatty acids and triacylglyceride levels. All improved on the dose-dependent basis.

The researchers additionally studied the effects associated with 5 grams associated with EGCG per kilogram associated with diet over a 10-week time period on mildly diabetic rats and found which glucose tolerance, blood glucose levels, and free fatty acid plasma concentrations all improved. Analysis of rat liver cells revealed that EGCG down-regulated the genetics involved in gluconeogenesis and the functionality of fatty acids, triacylglycerol as well as cholesterol.

"Our data suggest that supplementation with EGCG could potentially enhance glucose tolerance within humans with type-2 diabetes," concluded the researchers. "This hypothesis should certainly be investigated in randomized placebo-controlled tests." Wolfram said that DSM intends to begin such tests soon.

In the United States, a lot more than 20 million people suffer from diabetes -- about 7 percent from the population -- and about Nineteen million people within the European Union are so afflicted -- about Four percent of the populace. The cost of treating the disease is about $132 billion, based on the American Diabetes Association.

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